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Tumor Size as a Predictor of Outcome in Pediatric Non‐metastatic Osteosarcoma of the Extremity by Sue C. Kaste; T. Liu; C.A. Billups; N.C. Daw; C.B. Pratt; W.H. Meyer is a Medicine article available to read on EtoBox.

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## Abstract ## Background Better predictors of outcome would allow improved risk‐adapted therapy for pediatric nonmetastatic osteosarcoma of the extremity. We investigated the predictive value of MR imaging‐based measures of absolute and relative tumor size and volume at the time of diagnosis. We also assessed the relation of tumor size to age and histologic response. ## Methods We retrospectively abstracted demographic, treatment history, and outcome information of patients treated on a single institutional protocol. A single pediatric oncologic radiologist manually measured each primary lesion and the affected native bone in three dimensions on MR images obtained at the time of diagnosis. Eight parameters of tumor size were analyzed for their value in predicting overall survival (OS) and event‐free survival (EFS). ## Results The median age of the 42 patients was 13.5 years (range: 5.9–18.7 years); 50% were female and 74% were Caucasian. Absolute tumor volume was an important predictor of OS (__P__ < 0.05); absolute tumor depth (analyzed as a continuous variable) was a significant predictor of OS (__P__ = 0.018) and EFS (__P__ = 0.036). Relative measures of tumor size were not fou

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Author

Sue C. Kaste; T. Liu; C.A. Billups; N.C. Daw; C.B. Pratt; W.H. Meyer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2004

Language

EN

Field

Medicine (Health Sciences)