Can I read Smoking and Rheumatoid Arthritis on EtoBox?

Smoking and Rheumatoid Arthritis by Kathleen Chang; So Yang; Seong Kim; Kyoung Han; Se Park; Jae Shin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Smoking and Rheumatoid Arthritis about?

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by both genetic and environmental factors. Smoking has been implicated as one of the most important extrinsic risk factors for its development and severity. Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation and epigenetic changes. The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through __in vivo__ and animal models of RA. With increased use of biological agents in addition to standard disease-modifying antirheumatic drugs (DMARDs), there has been interest in how smoking affects drug response in RA treatment. Recent evidence suggests the response and drug survival in people treated with anti-tumour necrosis factor (anti-TNF) therapy is poorer in heavy smokers, and possible immunological mechanisms for this effect are presented in the current paper.

Who reads Smoking and Rheumatoid Arthritis?

Author

Kathleen Chang; So Yang; Seong Kim; Kyoung Han; Se Park; Jae Shin

Publisher

MDPI AG

Published

2014

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)