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Effects of the different administration frequencies of teriparatide (PTH [1‐34]) on new bone formation of expanded midpalatal sutures in rats: A histomorphometric and micro‐computed tomography analysis by Cansu Gül Koca; Sanaz Sadry; Hasan Asker; Muhammet Fatih Çiçek; Meryem Kösehasanoğulları; Gürkan Kaya is a Dentistry article available to read on EtoBox.
What is Effects of the different administration frequencies of teriparatide (PTH [1‐34]) on new bone formation of expanded midpalatal sutures in rats: A histomorphometric and micro‐computed tomography analysis about?
## Abstract ## Objective The aim of the study was to evaluate the effect of 4 μg/kg teriparatide administered at intermittent and continuous frequencies on bone formation in the expanded midpalatal suture region using histomorphometric and micro‐computed tomography (micro‐Ct) analysis. Settings and sample population: In this study, 24 Sprague Dawley male rats were used. ## Methods The experimental animals were divided into 3 groups as follows: Group 1: only maxillary expansion, Group 2: maxillary expansion with continuous teriparatide administration (2 μg in the morning and 2 μg in the evening) and Group 3: maxillary expansion with intermittent teriparatide administration (daily 4 μg/kg). The expansion appliance was fixed to maxillary incisors of all animals within the 5‐day expansion period, followed by a 12‐day retention phase. Animals were sacrificed at the end of the retention period, and specimens were evaluated by micro‐Ct and histomorphometric analysis respectively. ## Results The results of the histomorphometric analysis showed that Group 3 had the highest number of osteoblasts (1042 ± 90.76) (P < .01). In addition, the results of micro‐Ct analysis revealed that Group 3 had
Who reads Effects of the different administration frequencies of teriparatide (PTH [1‐34]) on new bone formation of expanded midpalatal sutures in rats: A histomorphometric and micro‐computed tomography analysis?
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- Cansu Gül Koca; Sanaz Sadry; Hasan Asker; Muhammet Fatih Çiçek; Meryem Kösehasanoğulları; Gürkan Kaya
- Publisher
- Wiley
- Published
- 2021
- Field
- Dentistry (Health Sciences)