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Age-associated Changes in Rich-club Organisation in Autistic and Neurotypical Human Brains by Takamitsu Watanabe; Geraint Rees is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Macroscopic structural networks in the human brain have a rich-club architecture comprising both highly inter-connected central regions and sparsely connected peripheral regions. Recent studies show that disruption of this functionally efficient organisation is associated with several psychiatric disorders. However, despite increasing attention to this network property, whether age-associated changes in rich-club organisation occur during human adolescence remains unclear. Here, analysing a publicly shared diffusion tensor imaging dataset, we found that, during adolescence, brains of typically developing (TD) individuals showed increases in rich-club organisation and inferred network functionality, whereas individuals with autism spectrum disorders (ASD) did not. These differences between TD and ASD groups were statistically significant for both structural and functional properties. Moreover, this typical age-related changes in rich-club organisation were characterised by progressive involvement of the right anterior insula. In contrast, in ASD individuals, did not show typical increases in grey matter volume and this relative anatomical immaturity was correlated with t

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Author

Takamitsu Watanabe; Geraint Rees

Publisher

Springer Science and Business Media LLC

Published

2015

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)