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Phase Separation on Deformable Membranes: interplay of mechanical coupling and dynamic surface geometry by Winter, Antonia; Liu, Yuhao; Ziepke, Alexander; Dadunashvili, George; Frey, Erwin is a scholarly article available to read on EtoBox.

What is Phase Separation on Deformable Membranes: interplay of mechanical coupling and dynamic surface geometry about?

The self-organization of proteins into enriched compartments and the formation of complex patterns are crucial processes for life on the cellular level. Liquid-liquid phase separation is one mechanism for forming such enriched compartments. When phase-separating proteins are membrane-bound and locally disturb it, the mechanical response of the membrane mediates interactions between these proteins. How these membrane-mediated interactions influence the steady state of the protein density distribution is thus an important question to investigate in order to understand the rich diversity of protein and membrane-shape patterns present at the cellular level. This work starts with a widely used model for membrane-bound phase-separating proteins. We numerically solve our system to map out its phase space and perform a careful, systematic expansion of the model equations to characterize the phase transitions through linear stability analysis and free energy arguments. We observe that the membrane-mediated interactions, due to their long-range nature, are capable of qualitatively altering the equilibrium state of the proteins. This leads to arrested coarsening and length-scale selection ins

Author

Winter, Antonia; Liu, Yuhao; Ziepke, Alexander; Dadunashvili, George; Frey, Erwin

Published

2024

Language

EN