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Cyclic adenosinemonophosphate in cerebrospinal fluid: Effects of theophylline, l-Dopa and a dopamine receptor stimulant in rats by Marika Kießling; Toni Lindl; Hinrich Cramer is a Medicine article available to read on EtoBox.

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The effects of L-Dopa and the dopamine receptor stimulant ET-495 on cisternal cAMP levels were studied in rats. L-dopa (100-200 mg/kg) increased cisternal cAMP levels by 60 to 80% of controls. When peripheral Dopa-decarboxylase was inhibited, smaller doses of L-Dopa were effective. Fla-63, an inhibitor of dopamine-beta-hydroxylase lowered the increase induced by L-Dopa which was completely suppressed by propranolol, not by phentolamine, suggesting that the cAMP increase is mediated through a central beta-adrenoceptor stimulation. ET-495 failed to influence cAMP levels which argues against a dopamine-sensitive adenylate cyclase involved in the L-Dopa effect. Moreover, large increases of cisternal cAMP were observed after treatment with theophylline , not papaverine which suggests different effects of these "phosphodiesterase inhibitors" on the cyclic AMP systems in the central nervous system or on transport mechanisms.

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Author

Marika Kießling; Toni Lindl; Hinrich Cramer

Publisher

Springer-Verlag; Dr. Dietrich Steinkopff Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1433-8491)

Published

1975

Language

EN

Field

Medicine (Health Sciences)