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This document summarizes the mechanisms of diabetic glucotoxicity caused by chronic hyperglycemia. It discusses two main types of stress: hyperglycemic stress and carbon stress. Hyperglycemic stress results from redox imbalance and activation of pathways like the polyol pathway, hexosamine pathway, advanced glycation end products pathway, and protein kinase C activation pathway. Carbon stress occurs due to excess production of acetyl-CoA and fumarate, leading to over-acetylation and over-succination of prot

Author

Ion Vasilescu

Language

EN