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Organic phosphorus compounds and carbamates are significant cholinesterase-inhibiting insecticides that cause substantial human toxicity, particularly in rural Asia where an estimated 200,000 deaths occur annually due to their use. The document discusses the history, pharmacology, and epidemiology of these insecticides, highlighting their classification, mechanisms of action, and the impact of regulatory measures on suicide rates. It emphasizes the need for effective management and treatment of poisoning ca

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