About this Medicine article
Randomized Trial of Effect of Bariatric Surgery on Blood Pressure After 5 Years by Carlos A. Schiavon; Alexandre B. Cavalcanti; Juliana D. Oliveira; Rachel H.V. Machado; Eliana V. Santucci; Renato N. Santos; Julia S. Oliveira; Lucas P. Damiani; Débora Junqueira; Helio Halpern; Frederico de L.J. Monteiro; Patricia M. Noujaim; Ricardo V. Cohen; Marcio G. de Sousa; Luiz A. Bortolotto; Otavio Berwanger; Luciano F. Drager is a Medicine article available to read on EtoBox.
BACKGROUND Obesity represents a major obstacle for controlling hypertension, the leading risk factor for cardiovascular mortality. OBJECTIVES The purpose of this study was to determine the long-term effects of bariatric surgery on hypertension control and remission. METHODS We conducted a randomized clinical trial with subjects with obesity grade 1 or 2 plus hypertension using at least 2 medications. We excluded subjects with previous cardiovascular events and poorly controlled type 2 diabetes. Subjects were assigned to Roux-en-Y gastric bypass (RYGB) combined with medical therapy (MT) or MT alone. We reassessed the original primary outcome (reduction of at least 30% of the total antihypertensive medications while maintaining blood pressure levels <140/90 mm Hg) at 5 years. The main analysis followed the intention-to-treat principle. RESULTS A total of 100 subjects were included (76% women, age 43.8 AE 9.2 years, body mass index: 36.9 AE 2.7 kg/m 2 ). At 5 years, body mass index was 36.40 kg/m 2 (95% CI: 35.28-37.52 kg/m 2 ) for MT and 28.01 kg/m 2 (95% CI: 26.95-29.08 kg/m 2 ) for RYGB (P < 0.001). Compared with MT, RYGB promoted a significantly higher rate of number of medication
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- Author
- Carlos A. Schiavon; Alexandre B. Cavalcanti; Juliana D. Oliveira; Rachel H.V. Machado; Eliana V. Santucci; Renato N. Santos; Julia S. Oliveira; Lucas P. Damiani; Débora Junqueira; Helio Halpern; Frederico de L.J. Monteiro; Patricia M. Noujaim; Ricardo V. Cohen; Marcio G. de Sousa; Luiz A. Bortolotto; Otavio Berwanger; Luciano F. Drager
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)