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Quantitative biopsy pathology for the prediction of pathologically organ-confined prostate carcinoma : A multiinstitutional validation study by Alexander Haese; Manisha Chaudhari; M. Craig Miller; Jonathan I. Epstein; Hartwig Huland; Juri Palisaar; Markus Graefen; Peter Hammerer; Edward C. Poole; Gerard J. O'Dowd; Alan W. Partin; Robert W. Veltri is a Medicine article available to read on EtoBox.
What is Quantitative biopsy pathology for the prediction of pathologically organ-confined prostate carcinoma : A multiinstitutional validation study about?
## Abstract ## BACKGROUND Quantitative biopsy pathology with prostate specific antigen significantly improves the prediction of pathologic stage in patients with clinically localized prostate carcinoma (PCa). The authors recently reported a computational model for predicting patient specific likelihood of organ confinement of PCa using biopsy pathology and clinical data. The current study validates the initial models and presents an new, improved tool for clinical decision making. ## METHODS The authors assessed 10 biopsy pathologic parameters and 2 clinical parameters using data from two institutions. Of 1287 patients, 798 men had pathologically organ confined (OC) PCa, 282 men had nonorgan‐confined disease with capsular penetration (NOC‐CP) only, and 207 men showed seminal vesicle or lymph node invasion (NOC‐AD) after undergoing pelvic lymphadenectomy and radical prostatectomy. Patient input data were evaluated by ordinal logistic (OLOGIT) and neural network (NN) models; and the likelihood of developing OC, NOC‐CP, or NOC‐AD disease was calculated for the combined and separate data sets and was compared with the results from original presentation. In addition, a new two‐output mo
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- Author
- Alexander Haese; Manisha Chaudhari; M. Craig Miller; Jonathan I. Epstein; Hartwig Huland; Juri Palisaar; Markus Graefen; Peter Hammerer; Edward C. Poole; Gerard J. O'Dowd; Alan W. Partin; Robert W. Veltri
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)