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Therapy for Persistent Hypercalcemic Hyperparathyroidism Post-renal Transplant: Cinacalcet Versus Parathyroidectomy by Gabriel Giollo Rivelli; Marcelo Lopes de Lima; Marilda Mazzali is a Medicine article available to read on EtoBox.

What is Therapy for Persistent Hypercalcemic Hyperparathyroidism Post-renal Transplant: Cinacalcet Versus Parathyroidectomy about?

## Background: Persistent hyperparathyroidism post-transplant is associated with increases in the incidence of cardiovascular events, fractures, and deaths. the aim of this study was to compare both therapeutic options available: parathyroidectomy (ptx) and the calcimimetic agent cinacalcet. ## Methods: A single center retrospective study including adult renal transplant recipients who developed hypercalcemia due to persistent hyperparathyroidism. inclusion criteria: pth > 65 pg/ml with serum calcium > 11.5 mg/dl at any time after transplant or serum calcium persistently higher than 10.2 mg/dl one year after transplant. patients treated with cinacalcet (n=46) were compared to patients treated with parathyroidectomy (n=30). follow-up period was one year. clinical and laboratory data were analyzed to compare efficacy and safety of both therapeutic modalities. ## Results: Ptx controlled calcemia faster (month 1 x month 6) and reached significantly lower levels at month 12 (9.1±1.2 vs 9.7±0.8 mg/dl, p < 0.05); ptx patients showed significantly higher levels of serum phosphate (3.8±1.0 vs 2.9±0.5 mg/dl, p < 0.05) and returned pth to normal levels (45±51 pg/ml). cinacalcet, despite contr

Who reads Therapy for Persistent Hypercalcemic Hyperparathyroidism Post-renal Transplant: Cinacalcet Versus Parathyroidectomy?

Author

Gabriel Giollo Rivelli; Marcelo Lopes de Lima; Marilda Mazzali

Publisher

FapUNIFESP (SciELO)

Published

2020

Language

EN

Field

Medicine (Health Sciences)