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Can I read Genetic Pain Loss Disorders on EtoBox?
Genetic Pain Loss Disorders by Annette Lischka; Petra Lassuthova; Arman Çakar; Christopher J. Record; Jonas Van Lent; Jonathan Baets; Maike F. Dohrn; Jan Senderek; Angelika Lampert; David L. Bennett; John N. Wood; Vincent Timmerman; Thorsten Hornemann; Michaela Auer-Grumbach; Yesim Parman; Christian A. Hübner; Miriam Elbracht; Katja Eggermann; C. Geoffrey Woods; James J. Cox; Mary M. Reilly; Ingo Kurth is a Medicine article available to read on EtoBox.
What is Genetic Pain Loss Disorders about?
Pain is mediated by subtypes of sensory neurons that project to the spinal cord and, subsequently, the brain stem and brain (Fig. ). In humans, generalized pain loss is very rare and is mostly genetic in origin (Box 1), although some disorders (for example, tertiary syphi lis and leprosy) can also cause regional painlessness 1 . Mendelian pain loss disorders are classified as congenital insensitivity to pain (CIP) or hereditary sensory neuro pathy (HSN) (TaBle ). The term hereditary sensory and autonomic neuropathy (HSAN) is used to refer to indi viduals with autonomic symptoms. For clarity, HSNs are subsumed under the term HSAN in this Primer. In addition to alterations in pain sensing, CIP and HSN are associated with a wide range of other symptoms that affect different organ systems.CIP is usually defined by its congenital onset whereas later onset is often referred to as HSAN; however, a uni form terminology is still lacking and the differences between CIP and HSAN are sometimes not clearly specified. Dominant forms of HSAN sometimes show incomplete penetrance and usually manifest later in life than recessive forms, which are often congenital 2,3 (TaBle 1); however, some subgrou
Who reads Genetic Pain Loss Disorders?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Annette Lischka; Petra Lassuthova; Arman Çakar; Christopher J. Record; Jonas Van Lent; Jonathan Baets; Maike F. Dohrn; Jan Senderek; Angelika Lampert; David L. Bennett; John N. Wood; Vincent Timmerman; Thorsten Hornemann; Michaela Auer-Grumbach; Yesim Parman; Christian A. Hübner; Miriam Elbracht; Katja Eggermann; C. Geoffrey Woods; James J. Cox; Mary M. Reilly; Ingo Kurth
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)