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A Novel Targeted Therapy System for Cervical Cancer: Co-Delivery System of Antisense LncRNA of MDC1 and Oxaliplatin Magnetic Thermosensitive Cationic Liposome Drug Carrier by Hui Ye; Xiaoying Chu; Zhensheng Cao; Xuanxuan Hu; Zihan Wang; Meiqi Li; Leyu Wan; Yongping Li; Yongge Cao; Zhanqiu Diao; Fengting Peng; Jinsong Liu; Lihua Xu is a Materials Science article available to read on EtoBox.

What is A Novel Targeted Therapy System for Cervical Cancer: Co-Delivery System of Antisense LncRNA of MDC1 and Oxaliplatin Magnetic Thermosensitive Cationic Liposome Drug Carrier about?

## Background This study was aimed to prepare a novel magnetic thermosensitive cationic liposome drug carrier for the codelivery of Oxaliplatin (OXA) and antisense lncRNA of MDC1 (MDC1-AS) to Cervical cancer cells and evaluate the efficiency of this drug carrier and its antitumor effects on Cervical cancer. ## Methods Thermosensitive magnetic cationic liposomes were prepared using thin-film hydration method. The OXA and MDC1-AS vectors were loaded into the codelivery system, and the in vitro OXA thermosensitive release activity, efficiency of MDC1-AS regulating MDC1, in vitro cytotoxicity, and in vivo antitumor activity were determined. ## Results The codelivery system had desirable targeted delivery efficacy, OXA thermosensitive release, and MDC1-AS regulating MDC1. Codelivery of OXA and MDC1-AS enhanced the inhibition of cervical cancer cell growth in vitro and in vivo, compared with single drug delivery. ## Conclusion The novel codelivery of OXA and MDC1-AS magnetic thermosensitive cationic liposome drug carrier can be applied in the combined chemotherapy and gene therapy for cervical cancer.

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Author

Hui Ye; Xiaoying Chu; Zhensheng Cao; Xuanxuan Hu; Zihan Wang; Meiqi Li; Leyu Wan; Yongping Li; Yongge Cao; Zhanqiu Diao; Fengting Peng; Jinsong Liu; Lihua Xu

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)