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## Abstract The incidence of catheter related bloodstream infections poses a substantial burden on patient’s life’s and well‐being. Estimated 2 – 6 % of patients suffer from catheter associated bloodstream infections (BSI). Reports on mortality of these patients are up to 30 % in addition to a substantial prolongation of hospital days. The estimated cost of therapy of a BSI is approximately 10 000 € per patient. There is a definitive need for antimicrobially active medical devices for prophylaxis. Endowment of catheters with antibiotics and desinfectants have substantial limitations regarding spectrum of activity, duration of activity and clinical efficacy. The oligodynamic activity of silver has the greatest potential for prevention of catheter related infections. Various technologies in particular surface coating of these medical devices have been advocated previously with limited success. A new technology with impregnation of the entire catheter matrix with billions of nanoparticles of silver^0^ which results in a surface of 2000 cm^2^/g polyurethane (PU) has been developed. Central venous catheters manufactured according to the technology of the first and second generation have

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Author

J. P. Guggenbichler

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0933-5137)

Published

2003

Language

DE

Field

Engineering (Physical Sciences)