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Lipidomic Analysis to Assess Oxidative Stress in Acute Coronary Syndrome and Acute Stroke Patients by Malý, Martin (author);Hajšl, Martin (author);Bechyňská, Kamila (author);Kučerka, Ondřej (author);Šrámek, Martin (author);Suttnar, Jiří (author);Hlaváčková, Alžběta (author);Hajšlová, Jana (author);Kosek, Vít (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Lipidomic Analysis to Assess Oxidative Stress in Acute Coronary Syndrome and Acute Stroke Patients about?

Alterations in lipid metabolism mediated by oxidative stress play a key role in the process of atherosclerosis and superimposed thrombosis; these can lead to acute coronary syndrome (ACS) and acute ischemic stroke (AIS). Multiple studies have shown that the formation of atheromatous lesions is initiated by oxidation of low-density lipoproteins incorporated into the intima of the vessel wall. Here, we studied lipids in plasma samples from three cohorts: 61 patients with ACS (group A), 49 patients with AIS (group D), and 82 controls (group K). Untargeted lipidomics based on high-performance liquid chromatography coupled to mass spectrometry (UHPLC-HRMS) was employed to obtain comprehensive information on whether relationships exist between these patient categories based on lipid patterns. In addition, malondialdehyde (MDA) as a standard marker of oxidative stress was monitored. The most characteristic lipids in group K were fatty acyls of hydroxyfatty acids (FAHFAs). As expected, MDA concentrations were the lowest in group K. Our findings can better explain ongoing pathologies, both acute and chronic, with the potential for future diagnosis and treatment.

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Author

Malý, Martin (author);Hajšl, Martin (author);Bechyňská, Kamila (author);Kučerka, Ondřej (author);Šrámek, Martin (author);Suttnar, Jiří (author);Hlaváčková, Alžběta (author);Hajšlová, Jana (author);Kosek, Vít (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)