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The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease by Federica Defendi; Nicole M. Thielens; Giovanna Clavarino; Jean-Yves Cesbron; Chantal Dumestre-Pérard is a Medicine article available to read on EtoBox.

What is The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease about?

The complement is a powerful cascade of the innate immunity and also acts as a bridge between innate and acquired immune defence. Complement activation can occur via three distinct pathways, the classical, alternative and lectin pathways, each resulting in the common terminal pathway. Complement activation results in the release of a range of biologically active molecules that significantly contribute to immune surveillance and tissue homeostasis. Several soluble and membrane-bound regulatory proteins restrict complement activation in order to prevent complement-mediated autologous damage, consumption and exacerbated inflammation. The crucial role of complement in the host homeostasis is illustrated by association of both complement deficiency and overactivation with severe and life-threatening diseases. Autoantibodies targeting complement components have been described to alter expression and/or function of target protein resulting in a dysregulation of the delicate equilibrium between activation and inhibition of complement. The spectrum of diseases associated with complement autoantibodies depends on which complement protein and activation pathway are targeted, ranging from auto

Who reads The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease?

Author

Federica Defendi; Nicole M. Thielens; Giovanna Clavarino; Jean-Yves Cesbron; Chantal Dumestre-Pérard

Publisher

Springer Science and Business Media LLC

Published

2019

Language

EN

Field

Medicine (Health Sciences)