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Effect of Selenium on Lung Injury Induced by Limb Ischemic Reperfusion Injury in Sprague-Dawley Rats by Dudy Arman Hanafy; Christha Zenithy Tamburian; Lisnawati Rachmadi; Gerald Aldian Wijaya; Widya Trianita Suwatri; Sugisman is a Medicine article available to read on EtoBox.
What is Effect of Selenium on Lung Injury Induced by Limb Ischemic Reperfusion Injury in Sprague-Dawley Rats about?
## Purpose Ischemia-reperfusion injury (IRI) plays an important role in the pathophysiology of acute limb ischemia, leading to damage to distant organs, including the lungs. A complex mechanism is involved in the formation of reactive oxygen species (ROS), release of inflammatory mediators, and neutrophil activation. One strategy to reduce the damage is administering selenium, an antioxidant enzyme component that can bind ROS and protect cells. This study aimed to compare the degree of lung injury due to limb IRI in Sprague-Dawley (SD) rats with selenium administration versus those without selenium treatment. ## Materials and Methods Fifteen male SD rats were divided into three groups: the control group (Group A), the ischemia-reperfusion with pre-reperfusion selenium (Group B), and the ischemia-reperfusion with post-reperfusion selenium (Group C). All animals underwent two hours of limb ischemia and three hours of reperfusion. Selenium was given intravenously at a dose of 0.2 mg/kg body weight. After reperfusion, lung specimens were histopathologically examined. ## Results The median degree of lung injury was severe in Group A, mild in Group B, and moderate in Group C (P=0.01). Po
Who reads Effect of Selenium on Lung Injury Induced by Limb Ischemic Reperfusion Injury in Sprague-Dawley Rats?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dudy Arman Hanafy; Christha Zenithy Tamburian; Lisnawati Rachmadi; Gerald Aldian Wijaya; Widya Trianita Suwatri; Sugisman
- Publisher
- The Korean Society for Vascular Surgery
- Published
- 2023
- Field
- Medicine (Health Sciences)