Can I read A First Principles Approach to Identifying Polymers for Use in Two-phase Partitioning Bioreactors on EtoBox?

A First Principles Approach to Identifying Polymers for Use in Two-phase Partitioning Bioreactors by J. Scott Parent; Marinha Capela; Julian T. Dafoe; Andrew J. Daugulis is a Engineering article available to read on EtoBox.

What is A First Principles Approach to Identifying Polymers for Use in Two-phase Partitioning Bioreactors about?

## Abstract **BACKGROUND:** Two‐phase partitioning bioreactors (TPPBs) employ an immiscible phase to partition toxic substrates/products to/away from cells to reduce cytotoxicity and improve bioprocess performance. Initially, immiscible organic solvents were used as the sequestering phase, and their selection included consideration of solute–solvent affinity, which can be predicted through first principles consideration of solute activity and phase equilibrium thermodynamics. Polymers can replace organic solvents in such systems, however, their selection has largely been via heuristic means, and a more fundamental approach is necessary for future success in rational polymer identification. **RESULTS:** Material properties (polymer crystallinity, solubility parameter, and glass transition temperature __T__~g~) were examined across several polymers and polyaromatic hydrocarbons as target solutes. All were shown to influence solute–polymer affinity. **CONCLUSION:** This first attempt at identifying physical/chemical properties that affect solute–polymer partitioning has been able to demonstrate some clear trends, and has allowed us to formulate a polymer selection guide, based on firs

Who reads A First Principles Approach to Identifying Polymers for Use in Two-phase Partitioning Bioreactors?

Author

J. Scott Parent; Marinha Capela; Julian T. Dafoe; Andrew J. Daugulis

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0268-2575)

Published

2012

Language

EN

Field

Engineering (Physical Sciences)