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Characterization of the dynamic shear properties of hyaline cartilage using high-frequency dynamic MR elastography by Orlando Lopez; Kimberly K. Amrami; Armando Manduca; Richard L. Ehman is a Medicine article available to read on EtoBox.

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## Abstract This work evaluated the feasibility of dynamic MR Elastography (MRE) to quantify structural changes in bovine hyaline cartilage induced by selective enzymatic degradation. The ability of the technique to quantify the frequency‐dependent response of normal cartilage to shear in the kilohertz range was also explored. Bovine cartilage plugs of 8 mm in diameter were used for this study. The shear stiffness (μ~s~) of each cartilage plug was measured before and after 16 hr of enzymatic treatments by dynamic MRE at 5000 Hz of shear excitation. Collagenase and trypsin were used to selectively affect the collagen and proteoglycans contents of the matrix. Additionally, normal cartilage plugs were tested by dynamic MRE at shear‐excitations of 3000–7000 Hz. Measured μ~s~ of cartilage plugs showed a significant decrease (−37%, __P__ < 0.05) after collagenase treatment and a significant decrease (−28%, __P__ < 0.05) after trypsin treatment. Furthermore, a near‐linear increase (R^2^ = 0.9141) in the speed of shear wave propagation with shear‐excitation frequency was observed in cartilage, indicating that wave speed is dominated by viscoelastic effects. These experiments suggest that d

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Author

Orlando Lopez; Kimberly K. Amrami; Armando Manduca; Richard L. Ehman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2008

Language

EN

Field

Medicine (Health Sciences)