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Improvements in Vascular Health by a Low-fat Diet, but Not a High-fat Diet, Are Mediated by Changes in Adipocyte Biology by Krista A Varady; Surabhi Bhutani; Monica C Klempel; Shane A Phillips is a Medicine article available to read on EtoBox.

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## Background Low-fat (LF) and high-fat (HF) weight loss diets improve brachial artery flow-mediated dilation (FMD) in obese individuals, although results are conflicting. Moreover, the role that adipose tissue plays in mediating these diet-related effects are unknown. ## Objective This study examined how modulations in FMD by HF and LF diets relate to changes in adipocyte parameters. ## Design Obese subjects (n = 17) were randomized to a HF diet (60% kcal as fat) or a LF diet (25% kcal as fat) for 6 weeks. Both groups were restricted by 25% of energy needs. ## Results Body weight decreased (__P <__0.05) in both groups (HF: -6.6 ± 0.5 kg, LF: -4.7 ± 0.6 kg). Fat mass and waist circumference were reduced (__P <__0.05) in the LF group only (-4.4 ± 0.3 kg; -3.6 ± 0.8 cm, respectively). FMD improved (__P <__0.05) in the LF group (7.4 ± 0.8% to 9.8 ± 0.8; 32% increase) and was impaired in the HF group (8.5 ± 0.6% to 6.9 ± 0.7; 19% reduction). Increases in plasma adiponectin (__P <__0.05, 16 ± 5%), and decreases in resistin (__P <__0.05, -26 ± 11%), were shown by the LF diet only. Greater decreases in leptin were observed with LF (-48 ± 9%) versus HF (-28 ± 12%) (__P <__0.05, diet × time

Who reads Improvements in Vascular Health by a Low-fat Diet, but Not a High-fat Diet, Are Mediated by Changes in Adipocyte Biology?

Author

Krista A Varady; Surabhi Bhutani; Monica C Klempel; Shane A Phillips

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Springer Nature (ISSN 1475-2891)

Published

2011

Language

EN

Field

Medicine (Health Sciences)