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Aggregation of amphotericin B in the presence of γ-cyclodextin: AGGREGATION OF AMPHOTERICIN B by M. Kajtár; M. Vikmon; E. Morlin; J. Szejtli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Aggregation of amphotericin B in the presence of γ-cyclodextin: AGGREGATION OF AMPHOTERICIN B about?

The macrolide antibiotic amphotericin B (AmB) forms an inclusion complex with y-cyclodextrin ( y-CDx), resulting in a molecularly dispersed state of the drug. The state of aggregation of AmB in different solvents has been studied by absorption (uv-vis) and CD spectroscopy. While in aqueous solutions AmB forms colloid-like multimolecular aggregates, in the presence of yCDx true solutions can be prepared, which show similar spectral properties as AmB dissolved in organic solvents. The AmB-yCDx complex can be isolated as an amorphous, stable, water-soluble powder, indicating that y-CDx is a good carrier for the solubilization of this antibiotic. Using y-CDx as a carrier, the danger of precipitation of the drug during parenteral or intravenous administration can be largely reduced.

Who reads Aggregation of amphotericin B in the presence of γ-cyclodextin: AGGREGATION OF AMPHOTERICIN B?

Author

M. Kajtár; M. Vikmon; E. Morlin; J. Szejtli

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0006-3525)

Published

1989

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)