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Large-scale (Phase III) evaluation of broflanilide 50WP (VECTRONTM T500) for indoor residual spraying for malaria vector control in Northeast Tanzania: study protocol for a two-arm, non-inferiority, cluster-randomised community trial by Patrick K. Tungu; Mark W. Rowland; Louisa A. Messenger; Graham J. Small; John Bradley; Janneke Snetselaar; Matthew J. Kirby; Njelembo J. Mbewe is a Medicine article available to read on EtoBox.

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## Abstract ## Background Indoor residual spraying (IRS) is a major method of malaria vector control across sub-Saharan Africa. Effective control is being undermined by the rapid spread of insecticide resistance. There is major investment in development of new insecticides for IRS that possess novel modes of action, long residual activity, low mammalian toxicity and minimal cross-resistance. VECTRONTM T500, a new IRS product containing the active ingredient broflanilide as a 50% wettable powder (WP), has been shown to be efficacious against pyrethroid susceptible and resistant vector species on mud and concrete substrates in experimental hut (Phase II) trials. ## Methods A two-arm non-inferiority cluster randomized controlled trial (Phase III) will be undertaken in Muheza District, Tanga Region, Tanzania. VECTRONTM T500 will be compared to the IRS product Fludora® Fusion (clothianidin 50% WP + deltamethrin 6.25% WP). The predominant malaria vectors in the study area are pyrethroid-resistant Anopheles gambiae s.s., An. arabiensis and An. funestus s.s. Sixteen village clusters will be pair-matched on baseline vector densities and allocated to reference and intervention arms. Consenti

Who reads Large-scale (Phase III) evaluation of broflanilide 50WP (VECTRONTM T500) for indoor residual spraying for malaria vector control in Northeast Tanzania: study protocol for a two-arm, non-inferiority, cluster-randomised community trial?

Author

Patrick K. Tungu; Mark W. Rowland; Louisa A. Messenger; Graham J. Small; John Bradley; Janneke Snetselaar; Matthew J. Kirby; Njelembo J. Mbewe

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)