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What gets on the nerves of cardiac patients? Pathophysiological changes in cardiac innervation by Courtney Clyburn; Joseph J. Sepe; Beth A. Habecker is a Neuroscience article available to read on EtoBox.

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## Abstract The autonomic nervous system regulates cardiac function by balancing the actions of sympathetic and parasympathetic inputs to the heart. Intrinsic cardiac neurocircuits integrate these autonomic signals to fine‐tune cardiac control, and sensory feedback loops regulate autonomic transmission in the face of external stimuli. These interconnected neural systems allow the heart to adapt to constantly changing circumstances that range from simple fluctuations in body position to running a marathon. The cardiac reflexes that serve to maintain homeostasis in health are disrupted in many disease states. This is often characterized by increased sympathetic and decreased parasympathetic transmission. Studies of cardiovascular disease reveal remodelling of cardiac neurocircuits at several functional and anatomical levels. Central circuits change so that sympathetic pathways become hyperactive, while parasympathetic circuits exhibit decreased activity. Peripheral sensory nerves also become hyperactive in disease, which increases patients’ risk for poor cardiac outcomes. Injury and disease also alter the types of neurotransmitters and neuropeptides released by autonomic nerves in th

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Author

Courtney Clyburn; Joseph J. Sepe; Beth A. Habecker

Publisher

Wiley

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)