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Kidney ultrastructural lesions in dogs experimentally infected with Dirofilaria immitis (Leidy, 1856) by E.C. Paes-de-Almeida; A.M.R. Ferreira; N.V. Labarthe; M.L.R. Caldas; J.W. McCall is a Immunology and Microbiology article available to read on EtoBox.

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Kidneys of 16 beagles with experimentally induced heartworm (Dirofilaria immitis) infections and 4 heartworm-nai;ve dogs were studied by light and electron microscopy. The infections were induced either by subcutaneous injection of infective larvae or by the transplantation of adult parasites, and infection periods varied from 111 to 818 days and 365 to 923 days, respectively. One control group of heartworm-naïve dogs and four groups of heartworm-infected dogs, which were divided according to the type and the length of infection, were used. In the infected dogs, thickening of the glomerular basement membrane (GBM), the presence of dense deposits in the GBM, and foot process effacement were the most frequent lesions observed. In some dogs, electron dense deposits were seen in the GBM and the mesangium and/or enlargement of the mesangial matrix could be characterized. The longer the infection period, the thicker the GBM and the more common the occurrence of foot process effacement. In general, these alterations were more evident in animals that had been infected for more than 1 year, had high microfilaremia, and had 14 or more parasites in the main pulmonary artery and its branches.

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Author

E.C. Paes-de-Almeida; A.M.R. Ferreira; N.V. Labarthe; M.L.R. Caldas; J.W. McCall

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0304-4017)

Published

2003

Language

EN

Field

Immunology and Microbiology (Life Sciences)