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Can I read Virus-induced electrotonic coupling: Hypothesis on the mechanism of periodic EEG discharges in Creutzfeldt-Jakob disease on EtoBox?
Virus-induced electrotonic coupling: Hypothesis on the mechanism of periodic EEG discharges in Creutzfeldt-Jakob disease by Dr. Roger D. Traub; Timothy A. Pedley is a Medicine article available to read on EtoBox.
What is Virus-induced electrotonic coupling: Hypothesis on the mechanism of periodic EEG discharges in Creutzfeldt-Jakob disease about?
## Abstract Experimental evidence and computer modeling indicate that periodic synchronous cellular depolarizing bursts (interictal spikes) arise when the balance between recurrent inhibition and local excitatory coupling is altered. Such a mechanism may explain the generalized periodic sharp waves that characterize the electroencephalogram of many patients with Creutzfeldt‐Jakob disease. In Creutzfeldt‐Jakob disease, fusions of neuronal processes, particularly dendrites, may lead to abnormal electrotonic coupling between cells, providing the basis for powerful excitatory interaction whereby large neuronal aggregates burst in near synchrony. Cortical synchronous discharges would give rise to sharp waves in the electroencephalogram, whereas similar discharges in brainstem, spinal cord, or elsewhere could lead to myoclonic jerks.
Who reads Virus-induced electrotonic coupling: Hypothesis on the mechanism of periodic EEG discharges in Creutzfeldt-Jakob disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dr. Roger D. Traub; Timothy A. Pedley
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)
- Published
- 1981
- Language
- EN
- Field
- Medicine (Health Sciences)