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This document describes the development and evaluation of transdermal patches containing diclofenac diethylammonium salt. Matrix-type patches were prepared using different ratios of polyvinylpyrrolidone and ethylcellulose with diclofenac diethylammonium salt. The patches were evaluated for physical properties, in vitro drug release, and in vitro and in vivo skin permeation. Formulations with PVP/EC ratios of 1:2 and 1:5 showed the best sustained release and skin permeation properties and were selected for f

Author

Selvi Silvia Emaliany

Language

EN