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Updated Cerebrospinal Fluid Total Protein Reference Values Improve Chronic Inflammatory Demyelinating Polyneuropathy Diagnosis by Ari Breiner; Pierre R. Bourque; Jeffrey A. Allen is a Medicine article available to read on EtoBox.

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## Introduction: Recent literature has concluded that cerebrospinal fluid total protein (csf-tp) upper reference limits (url) should be higher than 45 mg/dl and stratified by age. ## Methods: Data-driven urls were applied to the analysis of a cohort of patients with correctly and incorrectly diagnosed chronic inflammatory demyelinating polyneuropathy (cidp). descriptive statistics were calculated, and exploratory analyses were used to test the impact of different csf-tp urls on sensitivity and specificity of cidp diagnosis. ## Results: The adoption of higher and age-dependent csf-tp urls reduced the sensitivity of csf analysis slightly (from 95% to 84%-86%); however, the overall cidp detection rate was unchanged. twelve of 36 (33%) false-positive diagnoses occurred with csf-tp elevation as the sole supportive criteria. by applying updated csf-tp urls, the specificity of csf analysis increased from 39% to 57%-64%. ## Discussion: Implementation of data-driven csf-tp urls improves cidp diagnostic specificity without compromising sensitivity, thereby lessening cidp misdiagnosis. muscle nerve 60: 180-183, 2019.

Who reads Updated Cerebrospinal Fluid Total Protein Reference Values Improve Chronic Inflammatory Demyelinating Polyneuropathy Diagnosis?

Author

Ari Breiner; Pierre R. Bourque; Jeffrey A. Allen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)

Published

2019

Language

EN

Field

Medicine (Health Sciences)