Opening book details…
Can I read Biological Functions and Therapeutic Opportunities of Soluble Cytokine Receptors on EtoBox?
Biological Functions and Therapeutic Opportunities of Soluble Cytokine Receptors by Juliane Lokau; Christoph Garbers is a Immunology and Microbiology article available to read on EtoBox.
What is Biological Functions and Therapeutic Opportunities of Soluble Cytokine Receptors about?
Cytokines control the immune system by regulating the proliferation, differentiation and function of immune cells. They activate their target cells through binding to specific receptors, which either are transmembrane proteins or attached to the cell-surface via a GPI-anchor. Different tissues and individual cell types have unique expression profiles of cytokine receptors, and consequently this expression pattern dictates to which cytokines a given cell can respond. Furthermore, soluble variants of several cytokine receptors exist, which are generated by different molecular mechanisms, namely differential mRNA splicing, proteolytic cleavage of the membrane-tethered precursors, and release on extracellular vesicles. These soluble receptors shape the function of cytokines in different ways: they can serve as antagonistic decoy receptors which compete with their membrane-bound counterparts for the ligand, or they can form functional receptor/cytokine complexes which act as agonists and can even activate cells that would usually not respond to the ligand alone. In this review, we focus on the IL-2 and IL-6 families of cytokines and the so-called Th2 cytokines. We summarize for each cyt
Who reads Biological Functions and Therapeutic Opportunities of Soluble Cytokine Receptors?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Juliane Lokau; Christoph Garbers
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 1359-6101)
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)