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Can I read Simple and Reliable Gas Chromatographic Assay for the Determination of Carbamazepine in Plasma on EtoBox?
Simple and Reliable Gas Chromatographic Assay for the Determination of Carbamazepine in Plasma by Robin E. Chambers; Michael Cooke is a Chemistry article available to read on EtoBox.
What is Simple and Reliable Gas Chromatographic Assay for the Determination of Carbamazepine in Plasma about?
Therapeutic levels of carbamazepine in plasma are now determined routinely in many laboratories, and gas-liquid chromatography (GLC) is the technique generally employed 1 5. Unfortunately, carbamazepine has low thermal stability and in many GLC systems readily undergoes acid-catalysed hydrolysis to iminostilbene and rearrangement to 9-methylacridine 6, resulting in multiple peaks and poor reproducibility. To overcome this problem the use of derivatives, which may have greater thermal stability, has been suggested 7-9 but this introduces into the procedure an additional step which may be difficult to control. There is therefore a need for a simple and reliable GLC procedure in which carbamazepine can be chromatographed underivatised and give a single reproducible peak. In this paper, a system that fulfils these criteria is described.
Who reads Simple and Reliable Gas Chromatographic Assay for the Determination of Carbamazepine in Plasma?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Robin E. Chambers; Michael Cooke
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 1977
- Language
- EN
- Field
- Chemistry (Physical Sciences)