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Long‐term and in vivo assessment of Aβ protein‐induced brain atrophy in a zebrafish model by optical coherence tomography by Yanping Lin; Tingru Chen; Guangjuan Mao; Ting Qiu; Yintao Lan; Xiang Xiang; Jie Huang; Jing Huang; Ting Lu; Shuqi Gan; Xiang‐Dong Sun; Jian Zhang is a Engineering article available to read on EtoBox.
What is Long‐term and in vivo assessment of Aβ protein‐induced brain atrophy in a zebrafish model by optical coherence tomography about?
## Abstract In this study, a neurotoxicity model of zebrafish induced by amyloid beta (Aβ) protein was developed and evaluated in vivo by optical coherence tomography (OCT). Aβ protein and phosphate buffer saline (PBS) were separately injected into the head of two groups of adult zebrafish (n = 6 per group). Congo‐red staining results confirmed that Aβ protein had penetrated into brain tissue. All zebrafish were imaged with OCT on the 0th, 5th, 10th, 15th and 20th day postinjection. OCT images showed that PBS is not toxic to brain tissue. However, significant brain atrophy could be seen in the OCT images of zebrafish injected with Aβ‐protein that was verified by histological consequences. In addition, zebrafish in the model group showed memory decline in behavioral tests. This study verified the feasibility of in vivo long‐term assessment of Aβ protein‐induced brain atrophy in adult zebrafish by OCT that has great potential to be applied in the neurological diseases research.
Who reads Long‐term and in vivo assessment of Aβ protein‐induced brain atrophy in a zebrafish model by optical coherence tomography?
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- Author
- Yanping Lin; Tingru Chen; Guangjuan Mao; Ting Qiu; Yintao Lan; Xiang Xiang; Jie Huang; Jing Huang; Ting Lu; Shuqi Gan; Xiang‐Dong Sun; Jian Zhang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - VCH Verlag GmbH & CO. KGaA; Wiley (ISSN 1864-063X)
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)