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Fetal Origins of Adult Disease Fetal Origins Of Adult Disease? by Ruth Morley; Terence Dwyer is a Medicine article available to read on EtoBox.

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## SUMMARY 1. Associations between lower birthweight and higher blood pressure, increased risk of type 2 diabetes and coronary heart disease (CHD) have been observed in a number of different populations worldwide. 2. The reason for this is still debated. Some believe that the observed associations can be explained on the basis of differences in postnatal growth, socioeconomic confounding or genetic factors. Two published studies of birthweight and CHD, with information on later size, suggest that both gestational and postnatal exposures are important. Associations between birthweight and blood pressure, seen in cohorts of twins treated as individuals, have generally remained when data are analysed within twin pairs. Furthermore, similar associations are seen in studies of animals with relative genetic homogeneity kept in standard conditions. These findings suggest that neither socioeconomic nor genetic factors are wholly responsible for the observed associations. 3. If then, there is an underlying causal association, two issues are of fundamental importance. First, is fetal growth (for which birthweight is a summary measure) involved in the causal pathway or is the causal factor a

Who reads Fetal Origins of Adult Disease Fetal Origins Of Adult Disease??

Author

Ruth Morley; Terence Dwyer

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)

Published

2001

Language

EN

Field

Medicine (Health Sciences)