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Can I read Antiplasmodial and Cytotoxicity Evaluation of 3-Functionalized 2-Azetidinone Derivatives on EtoBox?
Antiplasmodial and Cytotoxicity Evaluation of 3-Functionalized 2-Azetidinone Derivatives by Pardeep Singh; Shaveta Sachdeva; Raghu Raj; Vipan Kumar; Mohinder P. Mahajan; Shereen Nasser; Livia Vivas; Jiri Gut; Phillip J. Rosenthal; Tzu-Shean Feng; Kelly Chibale is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Antiplasmodial and Cytotoxicity Evaluation of 3-Functionalized 2-Azetidinone Derivatives about?
3-Azido-, 3-amino- and 3-(1,2,3-triazol-1-yl)-β-lactams were synthesized and evaluated for their antiplasmodial activity against four strains of Plasmodium falciparum and KB cells for their cytotoxicity profiles. The presence of a cyclohexyl substituent at N-1 and a phenyl group on the triazole ring markedly improved the activity profiles of triazole-tethered β-lactam exhibiting IC(50) values of 1.13, 1.21 and 1.00 μM against 3D7, K1 and W2 strains respectively.
Who reads Antiplasmodial and Cytotoxicity Evaluation of 3-Functionalized 2-Azetidinone Derivatives?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Pardeep Singh; Shaveta Sachdeva; Raghu Raj; Vipan Kumar; Mohinder P. Mahajan; Shereen Nasser; Livia Vivas; Jiri Gut; Phillip J. Rosenthal; Tzu-Shean Feng; Kelly Chibale
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)