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What is Single-Cell Haplotyping via Sequencing about?

This document discusses a novel sequencing-based methodology called single-cell genotyping-by-sequencing (scGBS) for haplotyping and copy-number profiling of single cells, which enhances preimplantation genetic testing (PGT) for monogenic disorders. The method demonstrates its effectiveness in analyzing human and bovine embryos, revealing genetic variations and mosaicism. The study outlines the technical parameters and analysis pipeline established for accurate concurrent haplotyping and copy-number profili

Author

lfdyyxy

Language

EN