Can I read The upper respiratory tract microbiome of indigenous Orang Asli in north-eastern Peninsular Malaysia on EtoBox?

The upper respiratory tract microbiome of indigenous Orang Asli in north-eastern Peninsular Malaysia by David W. Cleary; Denise E. Morris; Rebecca A. Anderson; Jessica Jones; Ahmed Ghazi Alattraqchi; Nor Iza A. Rahman; Salwani Ismail; Mohd Sayuti Razali; Rahmah Mohd Amin; Aniza Abd Aziz; Nor Kamaruzaman Esa; Salman Amiruddin; Ching Hoong Chew; Hafis Simin; Ramle Abdullah; Chew Chieng Yeo; Stuart C. Clarke is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The upper respiratory tract microbiome of indigenous Orang Asli in north-eastern Peninsular Malaysia about?

## Abstract Much microbiome research has focused on populations that are predominantly of European descent, and from narrow demographics that do not capture the socio-economic and lifestyle differences which impact human health. Here we examined the airway microbiomes of the Orang Asli, the indigenous peoples of Malaysia. A total of 130 participants were recruited from two sites in the north-eastern state of Terengganu in Peninsular Malaysia. Using 16S rRNA sequencing, the nasal microbiome was significantly more diverse in those aged 5–17 years compared to 50+ years (p = 0.023) and clustered by age (PERMANOVA analysis of the Bray–Curtis distance, p = 0.001). Hierarchical clustering of Bray–Curtis dissimilarity scores revealed six microbiome clusters. The largest cluster (n = 28; 35.4%) had a marked abundance of Corynebacterium. In the oral microbiomes Streptococcus, Neisseria and Haemophilus were dominant. Using conventional microbiology, high levels of Staphylococcus aureus carriage were observed, particularly in the 18–65 age group (n = 17/36; 47.2% 95% CI: 30.9–63.5). The highest carriage of pneumococci was in the <5 and 5 to 17 year olds, with 57.1% (4/7) and 49.2% (30/61), res

Who reads The upper respiratory tract microbiome of indigenous Orang Asli in north-eastern Peninsular Malaysia?

Author

David W. Cleary; Denise E. Morris; Rebecca A. Anderson; Jessica Jones; Ahmed Ghazi Alattraqchi; Nor Iza A. Rahman; Salwani Ismail; Mohd Sayuti Razali; Rahmah Mohd Amin; Aniza Abd Aziz; Nor Kamaruzaman Esa; Salman Amiruddin; Ching Hoong Chew; Hafis Simin; Ramle Abdullah; Chew Chieng Yeo; Stuart C. Clarke

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)