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MON-345 Hypercalcemia After Placement of Antibiotic-Loaded Calcium Sulfate Beads by Kyrstin Lane; Sarah Kim; Shira Grock; Matthew Freeby is a Medicine article available to read on EtoBox.

What is MON-345 Hypercalcemia After Placement of Antibiotic-Loaded Calcium Sulfate Beads about?

## Abstract Calcium sulfate beads are used to fill bone voids in bone loss and nonunion, as well as in the management of bone and joint infections.^1^ Specifically, Stimulan® is an absorbed form of antibiotic-loaded calcium sulfate beads which delivers high local antibiotic concentrations for treatment of infection, but has also been associated with hypercalcemia in 5.4% of cases.^1^ Despite the significant morbidity associated with hypercalcemia, there is little published literature describing this important complication. In our institution, five patients hospitalized between March 2019 and September 2019 with normal baseline calcium levels developed hypercalcemia as a complication of Stimulan® placement. Typically, 10 to 60 cc of Stimulan® were inserted in each surgery, with the exception of 120cc in one surgery. Three patients required a second surgery with antibiotic bead placement, and hypercalcemia occurred with both initial and subsequent surgeries. The onset of hypercalcemia varied from post-operative day one to four. The peak corrected calcium was 10.7-16.1 mg/dL which corresponded to ionized calcium of 1.57 to >2.20 mmol/L (normal 1.09-1.29 mmol/L). The patient with the h

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Author

Kyrstin Lane; Sarah Kim; Shira Grock; Matthew Freeby

Publisher

The Endocrine Society

Published

2020

Language

EN

Field

Medicine (Health Sciences)