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Chiral separations in normal phase liquid chromatography: Enantioselectivity of recently commercialized polysaccharide-based selectors. Part I: Enantioselectivity under generic screening conditions by Ahmed A. Younes; Debby Mangelings; Yvan Vander Heyden is a Chemistry article available to read on EtoBox.
What is Chiral separations in normal phase liquid chromatography: Enantioselectivity of recently commercialized polysaccharide-based selectors. Part I: Enantioselectivity under generic screening conditions about?
Four recently commercialized polysaccharide-based chiral stationary phases, Sepapak ® 1, Sepapak ® 2, Sepapak ® 3, and Sepapak ® 4, now called Lux ® Cellulose-1, Lux ® Cellulose-2, Lux ® Amylose-2 and Lux ® Cellulose-4, respectively, were examined for their enantioselectivity on a set of 61 racemic compounds by applying the screening conditions of a previously developed chiral screening strategy in normal phase liquid chromatography (NPLC) [N. Matthijs et al., J. Chromatogr. A 1041 (2004) 119-133]. The enantioselectivity on these phases was compared to that on the initial set of polysaccharide-based phases, Chiralpak ® AD-H, Chiralcel ® OD-H, and Chiralcel ® OJ-H, used in the earlier defined strategy. The results showed that 53 compounds out of 61 (86.9%) were resolved on the initial set of chiral stationary phases (CSPs) using two mobile phases per compound, either heptane-ethanol-diethylamine (DEA) or heptane-isopropanol-DEA for testing basic compounds and heptane-ethanol-trifluoroacetic acid (TFA) or heptane-isopropanol-TFA for acidic, bifunctional and neutral compounds. The recently commercialized set of columns gave 54 separations in total (88.5%). Our results indicated that e
Who reads Chiral separations in normal phase liquid chromatography: Enantioselectivity of recently commercialized polysaccharide-based selectors. Part I: Enantioselectivity under generic screening conditions?
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- Author
- Ahmed A. Younes; Debby Mangelings; Yvan Vander Heyden
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 2011
- Language
- EN
- Field
- Chemistry (Physical Sciences)
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