Can I read The Effect of the Interruption of Agitation on Plateletquality During Storage for Transfusion on EtoBox?

The Effect of the Interruption of Agitation on Plateletquality During Storage for Transfusion by Suzanne Hunter; Janice Nixon; Scott Murphy is a Medicine article available to read on EtoBox.

What is The Effect of the Interruption of Agitation on Plateletquality During Storage for Transfusion about?

**BACKGROUND:** A considerable amount of data and the CFR suggest that platelet concentrates (PCs) should be stored with continuous, gentle agitation before transfusion. However, there are only limited data concerning the mechanisms of platelet damage that may occur when agitation is interrupted, and there are no CFR guidelines concerning shipment between periods of storage. **STUDY DESIGN AND METHODS:** PCs were prepared by the platelet‐rich plasma method and stored for 5 days at 20 to 24°C; agitation was interrupted for 1 to 3 days either by simply stopping the agitator or by placing the PCs in a stationary shipping container. Measurements of platelet metabolism and quality were made during storage and on Day 5. **RESULTS:** With interruption on the agitator, the production of lactic acid was increased during the interruption in proportion to the number of platelets in the PC and the duration of the interruption. The pO~2~ was increased during agitation interruption, which suggested a decline in oxygen utilization. With the use of the hypotonic shock response and the extent of shape change as reflections of platelet quality, there was no evidence of platelet damage unless the pH

Who reads The Effect of the Interruption of Agitation on Plateletquality During Storage for Transfusion?

Author

Suzanne Hunter; Janice Nixon; Scott Murphy

Publisher

Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)

Published

2001

Language

EN

Field

Medicine (Health Sciences)