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This study investigates the parameters of cocaine self-administration in rats using a progressive-ratio (PR) schedule, which requires an increasing number of lever presses for each successive cocaine dose. Results indicate that rats can quickly acquire and maintain stable self-administration behavior over extended periods, with the number of reinforcers obtained being a preferable measure for statistical analysis. Additionally, the dopamine receptor antagonist SCH23390 significantly reduced the breakpoint,
- Author
- Lenin Miranda
- Language
- EN