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Evaluating the Efficacy and Safety of Stereotactic Arrhythmia Radioablation in Ventricular Tachycardia: A Comprehensive Systematic Review and Meta-Analysis by Shah, Keyur D.; Chang, Chih-Wei; Tian, Sibo; Patel, Pretesh; Qiu, Richard; Roper, Justin; Zhou, Jun; Tian, Zhen; Yang, Xiaofeng is a scholarly article available to read on EtoBox.

What is Evaluating the Efficacy and Safety of Stereotactic Arrhythmia Radioablation in Ventricular Tachycardia: A Comprehensive Systematic Review and Meta-Analysis about?

Purpose: Stereotactic arrhythmia radioablation (STAR) has emerged as a promising non-invasive treatment for refractory ventricular tachycardia (VT), offering a novel alternative for patients who are poor candidates for catheter ablation. This systematic review and meta-analysis evaluates the safety, efficacy, and technical aspects of STAR across preclinical studies, case reports, case series, and clinical trials. Methods and Materials: A systematic review identified 80 studies published between 2015 and 2024, including 12 preclinical studies, 47 case reports, 15 case series, and 6 clinical trials. Data on patient demographics, treatment parameters, and clinical outcomes were extracted. Meta-analyses were performed for pooled mortality rates, VT burden reduction, and acute toxicities, with subgroup analyses exploring cardiomyopathy type, age, left ventricular ejection fraction (LVEF), and treatment modality. Results: The pooled 6- and 12-month mortality rates were 16% (95% CI: 11-21%) and 32% (95% CI: 26-39%), respectively. VT burden reduction at 6 months was 75% (95% CI: 73-77%), with significant heterogeneity (I^2 = 98.8%). Grade 3+ acute toxicities were observed in 7% (95% CI: 4-

Author

Shah, Keyur D.; Chang, Chih-Wei; Tian, Sibo; Patel, Pretesh; Qiu, Richard; Roper, Justin; Zhou, Jun; Tian, Zhen; Yang, Xiaofeng

Published

2025

Language

EN