Can I read Fronto‐temporal alterations within the first 200 ms during an attentional task distinguish major depression, non‐clinical participants with depressed mood and healthy controls: A potential biomarker? on EtoBox?

Fronto‐temporal alterations within the first 200 ms during an attentional task distinguish major depression, non‐clinical participants with depressed mood and healthy controls: A potential biomarker? by Andrew. H. Kemp; Patrick J. Hopkinson; Daniel F. Hermens; Donald L. Rowe; Alexander L. Sumich; C. Richard Clark; Wilhelmus Drinkenburg; Nadia Abdi; Rebecca Penrose; Alexander McFarlane; Philip Boyce; Evian Gordon; Leanne M. Williams is a Neuroscience article available to read on EtoBox.

What is Fronto‐temporal alterations within the first 200 ms during an attentional task distinguish major depression, non‐clinical participants with depressed mood and healthy controls: A potential biomarker? about?

## Abstract Attentional impairment in depression is a cardinal feature of depression and has been proposed as a candidate endophenotype for major depressive disorder. Event‐related potentials (ERPs) elicited by oddball signal detection tasks provide objective markers of selective stimulus processing, and are pertinent endophenotypic markers for depression. While previous studies have sought to determine objective markers for attentional impairment in depression, evidence is inconsistent and may involve heterogeneity in relatively small samples. Here, we brought together oddball ERP recording with source localization of neural correlates of selective attention in outpatients with major depressive disorder (MDD; __n__ = 78) and participants with depressed mood (PDM; __n__ = 127) relative to healthy controls (CTL; __n__ = 116). The key finding was a dimensional exaggeration of the P200 (140–270 ms) to both target (signal) and non‐target (noise) stimuli, most pronounced in MDD, followed by PDM, relative to CTL. This exaggeration was coupled with slower and more variable response times, suggesting that neural systems are attempting to compensate for a difficulty in discriminating signal

Who reads Fronto‐temporal alterations within the first 200 ms during an attentional task distinguish major depression, non‐clinical participants with depressed mood and healthy controls: A potential biomarker??

Author

Andrew. H. Kemp; Patrick J. Hopkinson; Daniel F. Hermens; Donald L. Rowe; Alexander L. Sumich; C. Richard Clark; Wilhelmus Drinkenburg; Nadia Abdi; Rebecca Penrose; Alexander McFarlane; Philip Boyce; Evian Gordon; Leanne M. Williams

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)