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Protective Effects of a Polyphenol-Rich Extract from Syzygium cumini (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats by Vinicyus Teles Chagas; Rafaella Moraes Rego de Sousa Coelho; Renato Simões Gaspar; Samira Abdalla da Silva; Mauricio Mastrogiovanni; Cáritas de Jesus Mendonça; Maria Nilce de Souza Ribeiro; Antonio Marcus de Andrade Paes; Andres Trostchansky is a Medicine article available to read on EtoBox.

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__Syzygium cumini__ (L.) Skeels has been reported to exert anti-inflammatory and cardiometabolic activities due to its high content of polyphenols. We characterized the chemical composition and assessed the antidiabetic effects of a novel polyphenol-rich extract (PESc) obtained from __S. cumini__ leaf. Rats were injected with alloxan (150 mg/kg, ip, ALX group) and followed up for 7 days. Some were orally treated with PESc (50 mg/kg/day) for 7 days before and after diabetes induction (ALX-PP) or only for 7 days after alloxan injection (ALX-P). ALX-P and ALX-PP decreased fasting glycemia in 37 and 43%, respectively, as compared to ALX. Triglycerides and total cholesterol serum levels were also significantly reduced in comparison to ALX. PESc presented high polyphenol concentration (71.78 ± 8.57 GAE/100 g), with flavonoid content of 8.21 ± 0.42 QE/100 g. Upon HPLC-MS/MS and MS/MS studies, five main polyphenols—gallic acid, quercetin, myricetin, and its derivatives—were identified. Myricetin was predominant (192.70 ± 16.50 __μ__g/mg PESc), followed by measurable amounts of gallic acid (11.15 ± 0.90 __μ__g/mg PESc) and quercetin (4.72 ± 0.06 __μ__g/mg PESc). Kinetic assessment of total

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Author

Vinicyus Teles Chagas; Rafaella Moraes Rego de Sousa Coelho; Renato Simões Gaspar; Samira Abdalla da Silva; Mauricio Mastrogiovanni; Cáritas de Jesus Mendonça; Maria Nilce de Souza Ribeiro; Antonio Marcus de Andrade Paes; Andres Trostchansky

Publisher

Hindawi Limited

Published

2018

Language

EN

Field

Medicine (Health Sciences)