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Tumour Progression and Metastatic Behaviour in Vivo Correlates with Integrin Expression on Melanocytic Tumours by Dr Dirk Schadendorf; Christian Gawlik; Uwe Haney; Hermann Ostmeier; Ludwig Suter; Beate M. Czarnetzki is a Medicine article available to read on EtoBox.

What is Tumour Progression and Metastatic Behaviour in Vivo Correlates with Integrin Expression on Melanocytic Tumours about?

## Abstract In order to evaluate the significance of adhesion molecules expressed on melanocytic tumours for progression and prognosis __in vivo__, we studied integrin expression (VLA‐1 to VLA‐6, CD18, CD51, CD61) on 10 naevi, 40 primary malignant melanomas, and 11 metastases by immunohistology using the APAAP technique. Evaluation was done by grouping the percentage of positive tumour cells in six categories. Statistical analysis (Wilcoxon rank test, Scheffe test) revealed significant differences in the expression of VLA‐1 (__P__ <0.0001), VLA‐2 (__P__=0.0001), VLA‐5 (__P__=0.0093), VLA‐6 (__P__=0.0232), and CD61 (__P__0.0002) between naevi and primary melanomas. Comparing primary melanomas with metastases, a statistically significant decrease in the expression of VLA‐1, VLA‐2, and VLA‐6 was detectable, as well as a significant increase in VLA‐4 and VLA‐5. There was no correlation between integrin expression and tumour type (superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma), regression and ulceration. Changes of VLA‐1, VLA‐4, and VLA‐6 expression correlated with the tumour thickness of the primary melanoma, but only VLA‐4 and VLA‐6 expression on primary m

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Author

Dr Dirk Schadendorf; Christian Gawlik; Uwe Haney; Hermann Ostmeier; Ludwig Suter; Beate M. Czarnetzki

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1993

Language

EN

Field

Medicine (Health Sciences)