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Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and prevention by Lois Bayigga; David P. Kateete; Deborah J. Anderson; Musa Sekikubo; Damalie Nakanjako is a Medicine article available to read on EtoBox.

What is Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and prevention about?

The vaginal microbial community (“microbiota”) is a key component of the reproductive health of women, providing protection against urogenital infections. In sub-Saharan Africa, there is a high prevalence of bacterial vaginosis, a condition defined by bacterial overgrowth and a shift away from a __Lactobacillus__-dominated profile toward increased percentages of strict anaerobic species. Bacterial vaginosis is associated with an increased risk of HIV acquisition and transmission, as well as an increased risk of acquiring other sexually transmitted infections, preterm births, and pelvic inflammatory disease. Vaginal microbiota, rich in taxa of strict anaerobic species, disrupts the mucosal epithelial barrier through secretion of metabolites and enzymes that mediate inflammation. Advancements in next-generation sequencing technologies such as whole-genome sequencing have led to deeper profiling of the vaginal microbiome and further study of its potential role in HIV pathogenesis and treatment. Until recently data on the composition of the vaginal microbiome in sub-Saharan Africa have been limited; however, a number of studies have been published that highlight the critical role of va

Who reads Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and prevention?

Author

Lois Bayigga; David P. Kateete; Deborah J. Anderson; Musa Sekikubo; Damalie Nakanjako

Published

2018

Language

EN

Field

Medicine (Health Sciences)