Opening book details…
Can I read Vinylogous Mannich reactions. Stereoselective formal synthesis of pumiliotoxin 251D on EtoBox?
Vinylogous Mannich reactions. Stereoselective formal synthesis of pumiliotoxin 251D by Stephen F. Martin; Scott K. Bur is a Chemistry article available to read on EtoBox.
What is Vinylogous Mannich reactions. Stereoselective formal synthesis of pumiliotoxin 251D about?
A concise synthesis of (-)-3, a known precursor of pumiliotoxin 251D, has been completed using a vinylogous Mannich reaction as a key construction. Silyloxyfuran 10 added to methoxypyrrolidine 20 in the presence of TMS-OTf to give a mixture (4.8:1) of 21 and 22 in 57% yield. Reduction and global deprotection of 21 afforded the bicyclic lactam 23. Raney Nickel mediated extrusion of the hydroxymethyl group from 23 gave (-)-3.
Who reads Vinylogous Mannich reactions. Stereoselective formal synthesis of pumiliotoxin 251D?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Stephen F. Martin; Scott K. Bur
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)
- Published
- 1999
- Language
- EN
- Field
- Chemistry (Physical Sciences)