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Development of a Novel Indwelling Balloon Applicator for Optimizing Light Delivery in Photodynamic Therapy by Steen J. Madsen; Chung-Ho Sun; Bruce J. Tromberg; Henry Hirschberg is a Medicine article available to read on EtoBox.

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## Abstract ## Background and Objective A human glioma spheroid model is used to investigate the efficacy of different light delivery schemes in 5‐aminolevulinic acid (ALA)—mediated photodynamic therapy (PDT). The results provide the rationale for the development of an indwelling balloon applicator for optimizing light delivery. ## Study Design/Materials and Methods Human glioma spheroids were incubated in ALA (100 or 1000 μg ml^−1^) for 4 hours and subjected to various light irradiation schemes. In one set of experiments, spheroid survival was monitored as a function of light fluence rate (5–200 mW cm^−2^). In all cases, spheroids were exposed to fluences of either 25 or 50 J cm^−2^. In a second study, the effects of repeated weekly PDT treatments, using sub‐threshold fluences, were investigated. One group of spheroids was subjected to three treatments using fluences of 12, 12, and 25 J cm^−2^. Results were compared to spheroids receiving single treatments of either 12 or 25 J cm^−2^. A fluence rate of 25 mW cm^−2^ was used for all three groups of spheroids. In all cases, the effect of a given irradiation scheme was evaluated by monitoring spheroid growth. ## Results Low fluence r

Who reads Development of a Novel Indwelling Balloon Applicator for Optimizing Light Delivery in Photodynamic Therapy?

Author

Steen J. Madsen; Chung-Ho Sun; Bruce J. Tromberg; Henry Hirschberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)

Published

2001

Language

EN

Field

Medicine (Health Sciences)