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A subset of CD8+ T cells from allergic patients produce IL-4 and stimulate IgE production in vitro by N. MEISSNER; E. KUSSEBI; T. JUNG; H. RATTI; C. BAUMGARTEN; T. WEREEL; C. HEUSSER; H. RENZ is a Medicine article available to read on EtoBox.

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## Background and objective: A subset of il-4 producing cd8+ t cells was recently identified in hiv patients. based on these findings we examined whether il-4 producing cd8+ t cells would also be present in allergic patients and what would be the functional relevance of this t-cell population. ## Methods: We investigated the role of cd8+ t cells in ige production of allergic diseases by analysing the cytokine profile of individual cd4+ and cd8+ t cells. ## Results: In allergic patients about twice as many cd4+ t cells and six times as many cd8+ t cells produced il-4 as in non-allergic controls. in contrast the frequency of ifngamma+ t-cell subsets did not significantly differ between the allergic and non-allergic individuals. the frequency of il4+ cd8+ t cells correlated with the level of serum ige. coculture experiments with t cells or purified cd8+ t cells together with autologous b cells indicated that cd8+ t cells enhanced ige in vitro, but not igm production, even when they were physically separated from b cells. this effect could be partially blocked by addition of an il-4 binding protein, a soluble il-4 receptor indicating that il-4 is involved in cd8+ t-cell mediated ige pr

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Author

N. MEISSNER; E. KUSSEBI; T. JUNG; H. RATTI; C. BAUMGARTEN; T. WEREEL; C. HEUSSER; H. RENZ

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)

Published

1998

Language

EN

Field

Medicine (Health Sciences)