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The Effect of Intravenous Ginkgolide on Clinical Improvement of Patients with Acute Ischemic Stroke by Dong, Yi; Li, Huiqin; Dong, Qiang is a Medicine article available to read on EtoBox.

What is The Effect of Intravenous Ginkgolide on Clinical Improvement of Patients with Acute Ischemic Stroke about?

: To compare the efficacy of ginkgolide in the treatment of Chinese patients with ischemic stroke between pre-marketing and post-marketing studies.: This is a re-analysis of a pre-marketing (phase II/III, multicenter, double-blind, parallel-controlled; February 2005 to September 2005) and post-marketing (phase IV, multicenter, open, single-arm registration; April 2013 to June 2014) studies. The intervention groups received intravenous ginkgolide (10 mL daily, 14 days). Primary outcome was an improvement of National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores after 14 days.: In pre- and post-marketing studies, NIHSS and mRS scores all improved, compared to that of baseline ( < 0.001) in acute phase. Those factors significantly associated with △NIHSS after 14 days of therapy with ginkgolide were grouping (pre-marketing vs. post-marketing; OR 2.169, 95%CI = 1.462-3.216, < 0.001), male (OR = 1.532, 95%CI = 1.152-2.037, = 0.003), enrollment within 30 days after onset (OR = 1.915, 95%CI = 1.452-2.526, < 0.001) and NIHSS score more than 8 points at baseline (OR = 15.140, 95%CI = 11.436-20.045, 8 points). Incidences of adverse reactions in the pre-marke

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Author

Dong, Yi; Li, Huiqin; Dong, Qiang

Publisher

Maney Publishing; Informa UK Limited (ISSN 0161-6412)

Published

2020

Language

EN

Field

Medicine (Health Sciences)