Can I read Activation of Transcription as a General Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Action on EtoBox?
Activation of Transcription as a General Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Action by Joan M. Fisher; Keith W. Jones; James P. Whitlock Jr. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Activation of Transcription as a General Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Action about?
We studied the response t o 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) of mouse hepatoma cells that contain a single, integrated copy o f a chimeric gene under the control of a dioxin-responsive DNA domain, which was originally associated with the cytochrome P450/A 7 gene. Our findings indicate that TCDD increases the RNA polymerase Il-catalyzed transcription rate of the chimeric gene and that the transcripts are initiated at the correct promoter. Therefore, the dioxin-responsive DNA operates as a bona fide transcriptional enhancer. Other studies imply that the Ah receptor mediates the transcriptional response t o TCDD. Our results indicate that the Ah receptor-dependent, dioxin-responsive enhancer can activate transcription when in a regulatory context and in a chromosomal location different from those o f the cytochrome P4501AI gene. Therefore, in principle, the receptor-enhancer system represents a mechanism by which numerous genes can respond to aromatic hydrocarbons in the environment.
Who reads Activation of Transcription as a General Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Action?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Joan M. Fisher; Keith W. Jones; James P. Whitlock Jr.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 1989
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)