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Urodilatin: a New Peptide with Beneficial Effects in the Postoperative Therapy of Cardiac Transplant Recipients by M. Hummel; M. Kuhn; A. Bub; H. Bittner; D. Kleefeld; P. Marxen; B. Schneider; R. Hetzer; W. G. Forssmann is a Medicine article available to read on EtoBox.

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Renal failure after heart transplantation (HTx) still remains a serious problem, especially when cyclosporin A is used for immunosuppression in the early postoperative therapy. To preserve good renal function without reducing immunosuppressive cyclosporin A treatment, we administered urodilatin (CDD/ANP-95-126) in a long-term, low-dose infusion in addition to the usual medication after heart transplantation. From November 1990 to June 1991, 51 patients (46 male and 5 female; mean age 48 years) were treated with a 6-20 ng/kg bw.min infusion for 96 h after HTx. The renal function and hemodynamic parameters of these urodilatin-treated patients were compared in this sequential study with 40 patients (33 male and 7 female; mean age 49 years) who had undergone HTx previously from May to November, 1990, as controls. In this phase IIa study, both groups did not differ significantly with respect to age, sex, indication for HTx, and preoperative renal function. In comparison with controls patients treated with urodilatin had a significantly better renal function: a reduction in the peak plasma creatinine (PC values day 4: 1.5 +/- 0.11 vs. 2.19 +/- 0.19 mg/dl; P = 0.002), a lower peak serum u

Who reads Urodilatin: a New Peptide with Beneficial Effects in the Postoperative Therapy of Cardiac Transplant Recipients?

Author

M. Hummel; M. Kuhn; A. Bub; H. Bittner; D. Kleefeld; P. Marxen; B. Schneider; R. Hetzer; W. G. Forssmann

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-1440)

Published

1992

Language

EN

Field

Medicine (Health Sciences)