Can I read Association of Visit-to-Visit Variability in Kidney Function and Serum Electrolyte Indexes With Risk of Adverse Clinical Outcomes Among Patients With Heart Failure With Preserved Ejection Fraction on EtoBox?

Association of Visit-to-Visit Variability in Kidney Function and Serum Electrolyte Indexes With Risk of Adverse Clinical Outcomes Among Patients With Heart Failure With Preserved Ejection Fraction by Matthew W. Segar; Ravi B. Patel; Kershaw V. Patel; Marat Fudim; Adam D. DeVore; Pieter Martens; S. Susan Hedayati; Justin L. Grodin; W. H. Wilson Tang; Ambarish Pandey is a Medicine article available to read on EtoBox.

What is Association of Visit-to-Visit Variability in Kidney Function and Serum Electrolyte Indexes With Risk of Adverse Clinical Outcomes Among Patients With Heart Failure With Preserved Ejection Fraction about?

## Importance: Although kidney dysfunction and abnormalities in serum electrolyte levels are associated with poor clinical outcomes in patients with heart failure with preserved ejection fraction (hfpef), the association of visit-to-visit variability in such laboratory measures with long-term outcomes is unclear. ## Objective: To evaluate the associations of visit-to-visit variability in indexes of kidney function (creatinine and blood urea nitrogen [bun] levels) and serum electrolyte (sodium, chloride, and potassium) with the risk of adverse clinical outcomes among patients with chronic, stable hfpef. ## Design, setting, and participants: This cohort analysis used data from the treatment of preserved cardiac function heart failure with an aldosterone antagonist (topcat) trial. all participants with 3 or more serial laboratory measurements who were event free within the first 4 months of enrollment were included. data were analyzed from march 1, 2019, to january 31, 2020. ## Main outcomes and measures: Adjusted associations between indexes of variability in serum laboratory measurements during the first 4 months of follow-up and risk of the primary composite outcome (a composite of

Who reads Association of Visit-to-Visit Variability in Kidney Function and Serum Electrolyte Indexes With Risk of Adverse Clinical Outcomes Among Patients With Heart Failure With Preserved Ejection Fraction?

Author

Matthew W. Segar; Ravi B. Patel; Kershaw V. Patel; Marat Fudim; Adam D. DeVore; Pieter Martens; S. Susan Hedayati; Justin L. Grodin; W. H. Wilson Tang; Ambarish Pandey

Publisher

American Medical Association; American Medical Association (AMA) (ISSN 2380-6583)

Published

2020

Language

EN

Field

Medicine (Health Sciences)